HAP1 and intracellular trafficking

Xiao-Jiang Li; Shi-Hua Li

doi:10.1016/j.tips.2004.11.001

HAP1 and intracellular trafficking

Trends Pharmacol Sci. 2005 Jan;26(1):1-3. doi: 10.1016/j.tips.2004.11.001.

Authors

Xiao-Jiang Li¹, Shi-Hua Li

Affiliation

¹ Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. xiaoli@genetics.emory.edu

PMID: 15629196
DOI: 10.1016/j.tips.2004.11.001

Abstract

Huntington's disease is caused by a polyglutamine expansion in the protein huntingtin. Several studies suggest that huntingtin and its associated protein HAP1 participate in intracellular trafficking and that polyglutamine expansion affects vesicular transport. A study now provides new evidence that HAP1 is also involved in the endocytosis of membrane receptors. These studies offer insight into the normal function of HAP1 and its involvement in Huntington's disease.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Humans
Huntington Disease / genetics
Huntington Disease / metabolism
Huntington Disease / physiopathology
Intracellular Signaling Peptides and Proteins / chemistry
Intracellular Signaling Peptides and Proteins / metabolism*
Nerve Tissue Proteins / chemistry
Nerve Tissue Proteins / metabolism*
Peptides / metabolism
Protein Transport / physiology

Substances

HAP1 protein, human
Intracellular Signaling Peptides and Proteins
Nerve Tissue Proteins
Peptides
polyglutamine