Abstract
Brains of 41 residents without neurodegenerative diseases in the high-incidence area of ALS/parkinsonism-dementia complex (ALS/PDC) of the Kii Peninsula of Japan were neuropathologically examined. Neurofibrillary tangles (NFTs) in the hippocampal area were present in 11 of the 41 cases, but the frequency of NFT-positive cases in each age group was similar to that of the normal Japanese population and far less than that of Guamanians without ALS/PDC.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Amyotrophic Lateral Sclerosis / epidemiology*
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Brain / pathology*
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Cause of Death
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Cerebrovascular Disorders / pathology
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Cluster Analysis
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Dementia / epidemiology*
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Female
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Hippocampus / pathology
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Humans
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Japan / epidemiology
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Liver Cirrhosis / pathology
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Male
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Middle Aged
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Myocardial Infarction / pathology
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Neoplasms / pathology*
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Neurofibrillary Tangles / pathology*
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Parkinson Disease / epidemiology*
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Prevalence
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Pulmonary Disease, Chronic Obstructive / pathology
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Violence