Abstract
Six new triterpenoid saponins were isolated as methyl or butyl esters from an n-BuOH extract of the roots of Symplocos chinensis. Their structures were established as symplocososides A (1), B (2), C (3), D (4), E (5), and F (6), by extensive 1D and 2D NMR as well as HR-MS analysis and chemical methods. Compounds 1, 3, and 6 were cytotoxic against one or more cell lines, and the derivative from 1 (1d) showed significant selectivities between KB cells and normal cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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KB Cells
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Medicine, Chinese Traditional
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Molecular Structure
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Saponins
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Triterpenes