Detection of gliotoxin in experimental and human aspergillosis

Infect Immun. 2005 Jan;73(1):635-7. doi: 10.1128/IAI.73.1.635-637.2005.

Abstract

Gliotoxin was measured in the lungs (mean, 3,976 +/- 1,662 ng/g of tissue) and sera (mean, 36.5 +/- 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amphotericin B / pharmacology
  • Animals
  • Aspergillosis / drug therapy
  • Aspergillosis / metabolism*
  • Female
  • Gliotoxin / analysis*
  • Humans
  • Lung / chemistry
  • Mice

Substances

  • Gliotoxin
  • Amphotericin B