This study was undertaken to evaluate the current status of shistosomiasis in the Nkolmébanga region (Lékié) of Cameroon, previously determined to be a mixed zone harboring both Schistosoma mansoni and S. intercalatum. Study involved both malacology with collection and identification of freshwater snails in four waterpools and parasitology with collection and analysis of stools from schoolchildren. Five species of freshwater snails were identified including two that were intermediate host of Schistosomes, i.e., Biomphalaria pfeifferi and Bulinus forskalii. Only B. pfeifferi species collected from the Momboh and Mbonsoh Rivers shed Schistosoma cercaria. A total of 347 schoolchildren were enrolled but only 200 provided stools for parasitological testing. There were 93 boys and 107 girls. Parisitology demonstrated S. intercalatum eggs in the stools of no children. S. mansoni eggs were identified in the stools of 10 children for a prevalence of 5%. Parasitic load ranged from 24 to 1104 eggs per gram of stool. In this study both malacologic and parasitological findings suggested that S. mansoni persists in Nkolmébanga region but that S. intercalatum has disappeared probably as a result of deforestation and urbanization.