Abstract
Loss-of-function mutations in the parkin gene, which encodes an E3 ubiquitin ligase, are the major cause of early-onset Parkinson's disease (PD). In this issue of Neuron, Kalia et al. show that the bcl-2-associated athanogene 5 (BAG5) enhances dopamine neuron death in an in vivo model of PD through inhibiting the E3 ligase activity of parkin and the chaperone activity of Hsp70.
MeSH terms
-
Adaptor Proteins, Signal Transducing / metabolism*
-
Animals
-
Carrier Proteins / metabolism*
-
HSP70 Heat-Shock Proteins / antagonists & inhibitors*
-
HSP70 Heat-Shock Proteins / metabolism*
-
Humans
-
Parkinson Disease / metabolism
-
Proto-Oncogene Proteins c-bcl-2 / metabolism*
-
Ubiquitin-Protein Ligases / antagonists & inhibitors*
-
Ubiquitin-Protein Ligases / metabolism*
Substances
-
Adaptor Proteins, Signal Transducing
-
Bag5 protein, rat
-
Carrier Proteins
-
HSP70 Heat-Shock Proteins
-
Proto-Oncogene Proteins c-bcl-2
-
Ubiquitin-Protein Ligases
-
parkin protein