Self-assembly of chiral DNA nanotubes

J Am Chem Soc. 2004 Dec 22;126(50):16342-3. doi: 10.1021/ja043890h.

Abstract

A system of DNA "tiles" that is designed to assemble to form two-dimensional arrays is observed to form narrow ribbons several micrometers in length. The uniform width of the ribbons and lack of frayed edges lead us to propose that they are arrays that have curled and closed on themselves to form tubes. This proposal is confirmed by the observation of tubes with helical order.

MeSH terms

  • Biotin / chemistry
  • DNA / chemistry*
  • DNA, Single-Stranded / chemistry
  • Horseradish Peroxidase / chemistry
  • Microscopy, Electron, Transmission
  • Models, Molecular
  • Nanotechnology / methods
  • Nanotubes / chemistry*
  • Nucleic Acid Conformation
  • Stereoisomerism
  • Streptavidin / chemistry

Substances

  • DNA, Single-Stranded
  • Biotin
  • DNA
  • Streptavidin
  • Horseradish Peroxidase