TAT conjugated, FITC doped silica nanoparticles for bioimaging applications

Chem Commun (Camb). 2004 Dec 21:(24):2810-1. doi: 10.1039/b411916a. Epub 2004 Oct 25.

Abstract

Water-in-oil (w/o) microemulsion synthesis of 70 nm size monodisperse TAT (a cell penetrating peptide, CPP) conjugated, FITC (fluorescein isothiocyanate) doped silica nanoparticles (TAT-FSNPs) is reported; human lung adenocarcinoma (A549) cells (in vitro) and rat brain tissue (in vivo) were successfully labeled using TAT-FSNPs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain / metabolism
  • Cell Line, Tumor
  • Emulsions / chemistry
  • Fluorescein-5-isothiocyanate / analysis*
  • Fluorescein-5-isothiocyanate / chemistry*
  • Gene Products, tat / chemistry*
  • Gene Products, tat / metabolism*
  • Humans
  • Microscopy, Electron, Transmission
  • Microscopy, Fluorescence
  • Nanostructures / chemistry*
  • Nanostructures / ultrastructure
  • Rats
  • Silicon Dioxide / chemistry*

Substances

  • Emulsions
  • Gene Products, tat
  • Silicon Dioxide
  • Fluorescein-5-isothiocyanate