Abstract
Water-in-oil (w/o) microemulsion synthesis of 70 nm size monodisperse TAT (a cell penetrating peptide, CPP) conjugated, FITC (fluorescein isothiocyanate) doped silica nanoparticles (TAT-FSNPs) is reported; human lung adenocarcinoma (A549) cells (in vitro) and rat brain tissue (in vivo) were successfully labeled using TAT-FSNPs.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain / metabolism
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Cell Line, Tumor
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Emulsions / chemistry
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Fluorescein-5-isothiocyanate / analysis*
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Fluorescein-5-isothiocyanate / chemistry*
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Gene Products, tat / chemistry*
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Gene Products, tat / metabolism*
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Humans
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Microscopy, Electron, Transmission
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Microscopy, Fluorescence
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Nanostructures / chemistry*
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Nanostructures / ultrastructure
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Rats
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Silicon Dioxide / chemistry*
Substances
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Emulsions
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Gene Products, tat
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Silicon Dioxide
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Fluorescein-5-isothiocyanate