Abstract
The synthesis of adamantylated pyrimidines was based on the reaction of 3-(adamantan-1-yl)-3-oxopropionic acid ethyl ester with urea, thiourea, guanidine as well as acetamidine, respectively. Then the compounds obtained were converted into respective bromo-, thio- and S-alkyl derivatives. The molecular structures for some compounds were studied by X-ray methods. The significant anticancer and antimicrobial properties of [2-(6-adamantan-1-yl-2-methylpyrimidin-4-ylthio)ethyl]dimethylamine were found.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adamantane
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Cell Line, Tumor
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Drug Evaluation, Preclinical / methods
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Humans
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Microbial Sensitivity Tests / statistics & numerical data
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Pyrimidines / chemistry*
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Pyrimidines / pharmacology*
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Antiviral Agents
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Pyrimidines
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Adamantane