Abstract
Oligoribonucleotides containing 4-thiouridine were prepared using the Fpmp group for protection of the 2'-OH. Two uridine derivatives with the 1,2,4-triazolyl and the 2-nitrophenyl groups at position 4 were used to obtain 4-thiouridine by postsynthetic substitution with sodium hydrogen sulfide. Both uridine derivatives allow the preparation of the desired oligonucleotides in good yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Nucleosides / chemistry*
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Oligoribonucleotides / chemical synthesis*
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Oligoribonucleotides / chemistry
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Oligoribonucleotides / metabolism
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Piperidines / chemistry*
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Thiouridine / chemistry*
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Thiouridine / metabolism
Substances
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1-(2-fluorophenyl)-4-methoxypiperidin-4-yl
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Nucleosides
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Oligoribonucleotides
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Piperidines
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Thiouridine