Helicobacter pylori and gastric autoimmunity

Microbes Infect. 2004 Dec;6(15):1395-401. doi: 10.1016/j.micinf.2004.10.001.

Abstract

Host specific T-cell response is critical for the outcome of Helicobacter pylori infection. In genetically susceptible individuals, H. pylori can activate gastric CD4+ Th1 cells that recognize cross-reactive epitopes shared by H. pylori proteins and self H+, K+-ATPase, leading to gastric autoimmunity via molecular mimicry.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, Bacterial / immunology
  • Autoantigens / immunology
  • Autoimmunity*
  • Gastritis / enzymology
  • Gastritis / immunology
  • Gastritis / microbiology*
  • Helicobacter Infections / immunology
  • Helicobacter pylori / immunology*
  • Humans

Substances

  • Antigens, Bacterial
  • Autoantigens