Abstract
Fucosterol isolated from Pelvetia siliquosa was tested for its anti-diabetic activity in vivo. Fucosterol, when administered orally at 30 mg/kg in streptozotocin-induced diabetic rats, was caused a significant decrease in serum glucose concentrations, and exhibited an inhibition of sorbitol accumulations in the lenses. Fucosterol, when administered orally at 300 mg/kg in epinephrine-induced diabetic rats, was also caused an inhibition of blood glucose level and glycogen degradation. These results demonstrated that fucosterol is a main anti-diabetic principle from the marine algae P. siliquosa.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Blood Glucose / drug effects
-
Blood Glucose / metabolism
-
Diabetes Mellitus, Experimental / blood
-
Diabetes Mellitus, Experimental / prevention & control*
-
Dose-Response Relationship, Drug
-
Liver / drug effects
-
Liver / metabolism
-
Liver Glycogen / metabolism
-
Male
-
Mice
-
Phaeophyceae / chemistry*
-
Rats
-
Rats, Sprague-Dawley
-
Rhodanine / analogs & derivatives*
-
Rhodanine / pharmacology
-
Stigmasterol / analogs & derivatives*
-
Stigmasterol / chemistry
-
Stigmasterol / isolation & purification
-
Stigmasterol / pharmacology*
-
Thiazolidines
Substances
-
Blood Glucose
-
Liver Glycogen
-
Thiazolidines
-
epalrestat
-
fucosterol
-
Rhodanine
-
Stigmasterol