In silico fine-mapping: narrowing disease-associated loci by intergenomics

Pablo Serrano-Fernández; Saleh M Ibrahim; Dirk Koczan; Uwe K Zettl; Steffen Möller

doi:10.1093/bioinformatics/bti209

In silico fine-mapping: narrowing disease-associated loci by intergenomics

Bioinformatics. 2005 Apr 15;21(8):1737-8. doi: 10.1093/bioinformatics/bti209. Epub 2004 Dec 10.

Authors

Pablo Serrano-Fernández¹, Saleh M Ibrahim, Dirk Koczan, Uwe K Zettl, Steffen Möller

Affiliation

¹ Institute of Immunology, University of Rostock, Schillingallee 70, D-18057 Rostock, Germany. serrano@pzr.uni-rostock.de

PMID: 15591355
DOI: 10.1093/bioinformatics/bti209

Abstract

Genetic linkage and association studies define quantitative trait loci (QTLs) and susceptibility loci (SLs) that influence the phenotype of polygenic traits. A web-accessible application was created to identify intergenomic consensuses to fine map QTLs and SLs in silico and select particularly promising candidate genes for such traits. Furthermore, this approach offers an empirical evaluation of animal models for their applicability to the study of human traits.

Availability: http://qtl.pzr.uni-rostock.de/qtlmix.php

Contact: serrano@pzr.uni-rostock.de.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chromosome Mapping / methods*
Genetic Predisposition to Disease / genetics*
Genetic Testing / methods*
Genomics / methods
Humans
Quantitative Trait Loci / genetics*
Sequence Alignment / methods*
Sequence Analysis, DNA / methods*
Software*