Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp

Sachiko Tsukamoto; Hiroshi Hirota; Misako Imachi; Masahiro Fujimuro; Hiroyuki Onuki; Tomihisa Ohta; Hideyoshi Yokosawa

doi:10.1016/j.bmcl.2004.10.012

Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp

Bioorg Med Chem Lett. 2005 Jan 3;15(1):191-4. doi: 10.1016/j.bmcl.2004.10.012.

Authors

Sachiko Tsukamoto¹, Hiroshi Hirota, Misako Imachi, Masahiro Fujimuro, Hiroyuki Onuki, Tomihisa Ohta, Hideyoshi Yokosawa

Affiliation

¹ Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920-1192, Japan. sachiko@p.kanakawa-u.ac.jp

PMID: 15582438
DOI: 10.1016/j.bmcl.2004.10.012

Abstract

A new ubiquitin-activating enzyme (E1) inhibitor, himeic acid A, was isolated from a culture of marine-derived fungus, Aspergillus sp. The structure was determined by spectroscopic analysis. The formation of an E1-ubiquitin (Ub) intermediate was 65% inhibited by himeic acid A at the concentration of 50 microM, while two new related compounds, himeic acids B and C, showed little inhibitory activity even at 100 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aspergillus / chemistry*
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Fatty Acids, Unsaturated / isolation & purification
Fatty Acids, Unsaturated / pharmacology*
Marine Biology*
Pyrones / isolation & purification
Pyrones / pharmacology*
Spectrometry, Mass, Fast Atom Bombardment
Ubiquitin-Activating Enzymes / antagonists & inhibitors*

Substances

Enzyme Inhibitors
Fatty Acids, Unsaturated
Pyrones
himeic acid A
Ubiquitin-Activating Enzymes