A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells

Kyung Noo Kim; Jiyong Lee; Dong Hoon Kim; Jong-Shin Yoo; Ho Jeong Kwon

doi:10.1016/j.bmcl.2004.10.039

A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells

Bioorg Med Chem Lett. 2005 Jan 3;15(1):77-9. doi: 10.1016/j.bmcl.2004.10.039.

Authors

Kyung Noo Kim¹, Jiyong Lee, Dong Hoon Kim, Jong-Shin Yoo, Ho Jeong Kwon

Affiliation

¹ Chemical Genomics National Research Laboratory, Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea.

PMID: 15582414
DOI: 10.1016/j.bmcl.2004.10.039

Abstract

Modified thymidine analogues have been highlighted as useful agents for the treatment of cancer and viral diseases due to their potent biological activities. In the present study, we synthesized a new thymidine analogue, 7-(3-bromo-phenoxy)-thymidine (4a), as a potential lead for anti-tumor agent. Compound 4a potently inhibits HeLa cell proliferation with an IC(50) of 15 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Division / drug effects*
HeLa Cells
Humans
Thymidine / analogs & derivatives*
Thymidine / chemical synthesis
Thymidine / chemistry
Thymidine / pharmacology*

Substances

7-(3-bromo-phenoxy)-thymidine
Thymidine