CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults

J Neuroimmunol. 2004 Dec;157(1-2):185-92. doi: 10.1016/j.jneuroim.2004.08.027.

Abstract

CCR2 is a minor coreceptor for human immune deficiency virus-1 (HIV-1) and its impact on HIV-1-related neuropsychological impairment (NPI) remains unknown. We studied the impact of CCR2-V64I polymorphisms on the development of NPI in 121 HIV-1 patients. The CCR2-64-I allele was associated with rate of progression to NPI when measured from the first study visit (Log Rank p=0.01) or from the estimated time of seroconversion (p=0.02). CCR2-V64I was not associated with plasma or CSF HIV-1 RNA load, suggesting that the impact of CCR2 on neuropathogenesis may involve alterations in inflammatory responses within the CNS rather than a direct impact on viral entry or replication.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Analysis of Variance
  • Chemokine CCL2 / genetics
  • Cognition Disorders / etiology*
  • Cognition Disorders / genetics*
  • Female
  • HIV / isolation & purification
  • HIV Infections / complications*
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Polymorphism, Genetic*
  • Receptors, CCR2
  • Receptors, CCR5 / genetics
  • Receptors, Chemokine / genetics*

Substances

  • CCL2 protein, human
  • CCR2 protein, human
  • Chemokine CCL2
  • Receptors, CCR2
  • Receptors, CCR5
  • Receptors, Chemokine