Abstract
Peptide mimics derived from the first extracellular loop of CCR5 bearing non-peptide spacers in place of Ala-Ala-Ala sequence in the peptide moiety were synthesized, and the effects of these compounds on the inhibition against HIV-1 were examined. Compound 2b having m-aminophenoxyacetic acid derivative as a non-peptide spacer significantly inhibited HIV-1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / pharmacology*
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Cell Line
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Chromatography, Thin Layer
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HIV-1 / drug effects*
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Humans
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Molecular Sequence Data
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Peptides / pharmacology*
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Receptors, CCR5 / chemistry*
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Receptors, CCR5 / drug effects
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Infrared
Substances
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Anti-HIV Agents
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Indicators and Reagents
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Peptides
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Receptors, CCR5