Novel intramolecular rearrangement leading to the synthesis of biheterocyclic indole-benzoimidazole derivatives on solid phase

Abhijeet Deb Roy; Sunil Sharma; Rajesh Kumar Grover; Bijoy Kundu; Raja Roy

doi:10.1021/ol0479794

Novel intramolecular rearrangement leading to the synthesis of biheterocyclic indole-benzoimidazole derivatives on solid phase

Org Lett. 2004 Dec 9;6(25):4763-6. doi: 10.1021/ol0479794.

Authors

Abhijeet Deb Roy¹, Sunil Sharma, Rajesh Kumar Grover, Bijoy Kundu, Raja Roy

Affiliation

¹ Division of SAIF, Central Drug Research Institute, Lucknow 226001, India.

PMID: 15575680
DOI: 10.1021/ol0479794

Abstract

[reaction: see text] A novel intramolecular SNAr rearrangement observed during the S-alkylation of benzoimidazole-2-thione with alpha-haloacetophenone is reported. The rearrangement led to the formation of a new benzoimidazole-based intermediate, which is further utilized for the generation of a new biheterocyclic indole-benzimidazole derivatives with a two-point diversity.