Abstract
Modulating protein-protein interactions involved in disease pathways is an attractive strategy for developing drugs, but remains a challenge to achieve. One approach is to target certain domains within proteins that mediate these interactions. One example of such a domain is the PDZ domain, which is involved in interactions between many different proteins in a variety of cellular contexts. Because PDZ domains have well-defined binding sites, they are promising targets for drug discovery. However, there is still much to learn about the function of these domains before drugs targeting PDZ interactions can become a reality.
MeSH terms
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Animals
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Carrier Proteins / antagonists & inhibitors
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Carrier Proteins / metabolism
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Drug Delivery Systems / methods*
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Humans
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Membrane Proteins / antagonists & inhibitors
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Membrane Proteins / metabolism*
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Nerve Tissue Proteins / antagonists & inhibitors
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Nerve Tissue Proteins / metabolism*
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Nuclear Proteins / antagonists & inhibitors
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Nuclear Proteins / metabolism
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Phosphoproteins / antagonists & inhibitors
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Phosphoproteins / metabolism*
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Protein Binding / drug effects
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Protein Structure, Tertiary / drug effects
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Proteins / antagonists & inhibitors
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Proteins / metabolism*
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SAP90-PSD95 Associated Proteins
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Zonula Occludens-1 Protein
Substances
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Carrier Proteins
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Membrane Proteins
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Nerve Tissue Proteins
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Nuclear Proteins
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PICk1 protein, human
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Phosphoproteins
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Proteins
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SAP90-PSD95 Associated Proteins
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TJP1 protein, human
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Zonula Occludens-1 Protein
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postsynaptic density proteins