Although HIV prevalence is low in the Republic of Yemen, existing conditions could lead to the rapid spread of HIV/AIDS. Interviewers helped 1033 residents aged 14-49 years from randomly chosen households to complete a survey of knowledge, attitudes and beliefs about HIV/AIDS. General awareness was good, although there were many misconceptions about transmission modes, stigmas and discrimination against HIV positive persons. Knowledge was significantly determined by schooling, residence and sex. Although they recognized the global threat of AIDS, participants underestimated its threat to the Republic of Yemen. Television was the commonest source of information. Fostering public awareness is recommended to facilitate the development of intervention programmes, fight stigmas and ensure delivery of care to those affected.