Concomitant information in bioassay and semi-parametric estimation

Stat Med. 2005 May 15;24(9):1421-33. doi: 10.1002/sim.1973.

Abstract

This paper presents a flexible modern approach to handling concomitant information for estimating the relative potency parameter in quantitative bioassays. This is accomplished in a semi-parametric framework where the concomitant variable is included non-parametrically. Estimation is then performed using smoothing splines where the point and interval estimators of the relative potency parameter exhibits desirable asymptotic properties.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Assay / methods*
  • Computer Simulation
  • Data Interpretation, Statistical*
  • Drug Evaluation / methods*
  • Models, Statistical*