Effect of azithromycin therapy on coronary circulation in patients with coronary artery disease

Eiichi Hyodo; Takeshi Hozumi; Yasuhiko Takemoto; Kohei Fujimoto; Hiroyuki Watanabe; Takashi Muro; Kenei Shimada; Kaname Akioka; Minoru Yoshiyama; Kazuhide Takeuchi; Junichi Yoshikawa

doi:10.1016/j.amjcard.2004.08.018

Effect of azithromycin therapy on coronary circulation in patients with coronary artery disease

Am J Cardiol. 2004 Dec 1;94(11):1426-9. doi: 10.1016/j.amjcard.2004.08.018.

Authors

Eiichi Hyodo¹, Takeshi Hozumi, Yasuhiko Takemoto, Kohei Fujimoto, Hiroyuki Watanabe, Takashi Muro, Kenei Shimada, Kaname Akioka, Minoru Yoshiyama, Kazuhide Takeuchi, Junichi Yoshikawa

Affiliation

¹ Department of Internal Medicine and Cardiology, Osaka City University School of Medicine, Osaka, Japan.

PMID: 15566918
DOI: 10.1016/j.amjcard.2004.08.018

Abstract

This study examined the effect of azithromycin therapy on the coronary microcirculation using measurement of coronary flow velocity reserve (CFVR) by transthoracic Doppler echocardiography in 35 patients with coronary artery disease. CFVR increased significantly after azithromycin therapy (3.0 +/- 0.7 vs 3.5 +/- 0.7, p <0.001). The changes in CFVR were negatively correlated with changes in high-sensitivity C-reactive protein levels in patients receiving azithromycin.

Publication types

Clinical Trial
Randomized Controlled Trial

MeSH terms

Aged
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use*
Azithromycin / pharmacology*
Azithromycin / therapeutic use*
C-Reactive Protein / analysis
Coronary Artery Disease / complications*
Coronary Artery Disease / drug therapy*
Coronary Vessels / physiology
Double-Blind Method
Echocardiography
Female
Humans
Male
Middle Aged
Myocardium
Prospective Studies
Regional Blood Flow

Substances

Anti-Bacterial Agents
Azithromycin
C-Reactive Protein