Abstract
Pantothenate is an essential metabolite for all biological systems, however, the biosynthetic pathway is limited to plants, eubacteria and archaea. This suggests that the pathway is a strong candidate for the discovery of novel antibiotic and herbicidal compounds. The enzymology of this short pathway in both bacteria and plants is discussed in detail. In addition a short survey of studies of the whole pathway, and a discussion of both the metabolism and the transport of pantothenate are included.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Arabidopsis / enzymology
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Arabidopsis / genetics
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Arabidopsis / metabolism
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Bacteria / enzymology
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Bacteria / genetics
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Bacteria / metabolism
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Models, Molecular
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Molecular Sequence Data
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Pantothenic Acid / biosynthesis*
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Peptide Synthases / metabolism*
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Saccharomyces cerevisiae / enzymology
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism
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Sequence Analysis, Protein
Substances
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Pantothenic Acid
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Peptide Synthases
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pantothenate synthetase