Expression of the MDR1 and MRP genes in patients with lymphoma with primary bone marrow involvement

A N Zenkov; N V Scvortsova; E L Chernolovskaya; T I Pospelova; V V Vlassov

doi:10.1081/NCN-200026029

Expression of the MDR1 and MRP genes in patients with lymphoma with primary bone marrow involvement

Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(6-7):843-7. doi: 10.1081/NCN-200026029.

Authors

A N Zenkov¹, N V Scvortsova, E L Chernolovskaya, T I Pospelova, V V Vlassov

Affiliation

¹ Institute of Chemical Biology and Fundamental Medicine, SB RAS, Russia. antzen@niboch.nsc.ru

PMID: 15560070
DOI: 10.1081/NCN-200026029

Abstract

Expression of MDR1 and MRP genes in patients with low-grade and high-grade non-Hodgkin's lymphomas with primary bone marrow involvement before and after chemotherapy was investigated. The data demonstrate that overexpression of MDR1 and MRP genes in hematological malignancies elevates in patients after chemotherapy and correlates with poor clinic prognosis and more frequent recurrences of the malignancies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / therapeutic use
Base Sequence
Bone Marrow / pathology*
DNA Primers
Genes, MDR*
Humans
Lymphoma, Non-Hodgkin / drug therapy
Lymphoma, Non-Hodgkin / genetics*
Lymphoma, Non-Hodgkin / pathology
Multidrug Resistance-Associated Proteins / genetics*

Substances

Antineoplastic Agents
DNA Primers
Multidrug Resistance-Associated Proteins