Clinical correlation between effective anticoagulants and risk of stroke: are we using evidence-based strategies?

South Med J. 2004 Oct;97(10):924-31. doi: 10.1097/01.SMJ.0000129930.40928.3F.

Abstract

Objectives: Despite evidence supporting anticoagulant use in atrial fibrillation, this modality is not fully utilized.

Methods: Retrospective chart review of 297 patients with nonvalvular atrial fibrillation between 1997 to 2000. 124 patients received warfarin and 166 did not; 91 patients suffered stroke.

Results: Age (P = 0.232) and gender (P = 0.745) were not determinant factors for starting anticoagulation prophylaxis. Whites were more likely to receive anticoagulation therapy than blacks (P = 0.043). Cardiologists were 4.5 times more likely to prescribe warfarin than neurologists and internists (P = 0.035). Neurologists (P = 0.305) and internists (P = 0.770) had similar warfarin prescription patterns and often with patients experiencing the highest rates of stroke.

Conclusion: Lack of a uniform pattern in anticoagulant administration, despite multiple guidelines, is disturbing. Continuous physician education and community awareness by local and federal medical agencies is essential and cost-effective.

MeSH terms

  • Adult
  • Aged
  • Anticoagulants / therapeutic use*
  • Atrial Fibrillation / complications
  • Atrial Fibrillation / drug therapy*
  • Comorbidity
  • Evidence-Based Medicine
  • Female
  • Georgia
  • Humans
  • International Normalized Ratio
  • Logistic Models
  • Male
  • Medicine
  • Middle Aged
  • Retrospective Studies
  • Specialization
  • Stroke / etiology
  • Stroke / prevention & control*
  • Warfarin / therapeutic use*

Substances

  • Anticoagulants
  • Warfarin