Abstract
Crossovers ensure proper chromosome segregation in meiosis. A heterodimer of MutS proteins, hMSH4-hMSH5, has recently been found to interact with recombination intermediates in a manner that suggests a mechanism for directing meiotic DNA double strand break repair towards a crossover pathway.
MeSH terms
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Adenosine Triphosphatases / metabolism*
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Bacterial Proteins / metabolism*
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Cell Cycle Proteins / metabolism
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Chromosome Segregation / physiology*
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Crossing Over, Genetic / physiology*
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DNA Repair / physiology*
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DNA, Cruciform / physiology
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DNA-Binding Proteins / metabolism*
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Meiosis / physiology*
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MutS DNA Mismatch-Binding Protein
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Proteins / metabolism
Substances
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Bacterial Proteins
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Cell Cycle Proteins
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DNA, Cruciform
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DNA-Binding Proteins
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MSH4 protein, human
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Proteins
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Adenosine Triphosphatases
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MutS DNA Mismatch-Binding Protein