Meiotic recombination: sealing the partnership at the junction

Curr Biol. 2004 Nov 23;14(22):R962-4. doi: 10.1016/j.cub.2004.10.043.

Abstract

Crossovers ensure proper chromosome segregation in meiosis. A heterodimer of MutS proteins, hMSH4-hMSH5, has recently been found to interact with recombination intermediates in a manner that suggests a mechanism for directing meiotic DNA double strand break repair towards a crossover pathway.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / metabolism*
  • Bacterial Proteins / metabolism*
  • Cell Cycle Proteins / metabolism
  • Chromosome Segregation / physiology*
  • Crossing Over, Genetic / physiology*
  • DNA Repair / physiology*
  • DNA, Cruciform / physiology
  • DNA-Binding Proteins / metabolism*
  • Meiosis / physiology*
  • MutS DNA Mismatch-Binding Protein
  • Proteins / metabolism

Substances

  • Bacterial Proteins
  • Cell Cycle Proteins
  • DNA, Cruciform
  • DNA-Binding Proteins
  • MSH4 protein, human
  • Proteins
  • Adenosine Triphosphatases
  • MutS DNA Mismatch-Binding Protein