Abstract
Gonad morphogenesis in Caenorhabditis elegans requires two secreted proteases. Recent studies show that alterations of the extracellular matrix component fibulin-1 rescue gonadogenesis in the absence of these proteases. This finding is a critical step toward understanding the role of extracellular matrix in organogenesis.
MeSH terms
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Animals
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Caenorhabditis elegans / growth & development*
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Caenorhabditis elegans Proteins / metabolism
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Calcium-Binding Proteins / metabolism*
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Cell Movement / physiology
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Extracellular Matrix / metabolism*
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Gonads / growth & development*
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Metalloendopeptidases / metabolism
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Organogenesis / physiology*
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Signal Transduction / physiology
Substances
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Caenorhabditis elegans Proteins
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Calcium-Binding Proteins
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fibulin
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GON-1 protein, C elegans
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Metalloendopeptidases