Synthesis and in vitro cytotoxicity of- 1,3-dioxoindan-2-carboxylic acid arylamides

Jae-Kyung Jung; Jinhyeong Ryu; Sung-Il Yang; Jungsook Cho; Heesoon Lee

doi:10.1007/BF02975420

Synthesis and in vitro cytotoxicity of- 1,3-dioxoindan-2-carboxylic acid arylamides

Arch Pharm Res. 2004 Oct;27(10):997-1000. doi: 10.1007/BF02975420.

Authors

Jae-Kyung Jung¹, Jinhyeong Ryu, Sung-Il Yang, Jungsook Cho, Heesoon Lee

Affiliation

¹ College of Pharmacy, Chungbuk National University, Cheongju, 361-763, Korea.

PMID: 15554253
DOI: 10.1007/BF02975420

Abstract

A series of 1,3-dioxoindan-2-carboxylic acid arylamides were synthesized and evaluated for in vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, MD-MB-468 and T-47D). The most active was compound 3e (1.2 microM against SK-OV-3 cell line) bearing a 4-methyl substituent.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides / chemical synthesis*
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Survival / drug effects
Drug Screening Assays, Antitumor
Humans
Indans / chemical synthesis*
Indans / pharmacology*
Structure-Activity Relationship

Substances

Amides
Antineoplastic Agents
Indans