Synthesis and antifungal activity of 5,8-quinazolinedione derivatives modified at positions 6 and 7

Chung-Kyu Ryu; Ju-Yeon Shim; You-Jin Yi; Ik Hwa Choi; Mi Jin Chae; Ja-Young Han; Ok-Jai Jung

doi:10.1007/BF02975419

Synthesis and antifungal activity of 5,8-quinazolinedione derivatives modified at positions 6 and 7

Arch Pharm Res. 2004 Oct;27(10):990-6. doi: 10.1007/BF02975419.

Authors

Chung-Kyu Ryu¹, Ju-Yeon Shim, You-Jin Yi, Ik Hwa Choi, Mi Jin Chae, Ja-Young Han, Ok-Jai Jung

Affiliation

¹ College of Pharmacy, Ewha Womans University, Sodaemun-Ku, Seoul 120-750, Korea. ckryu@mm.ewha.ac.kr

PMID: 15554252
DOI: 10.1007/BF02975419

Abstract

5,8-Quinazolinediones modified at positions 6 and 7 were synthesized and tested for in vitro antifungal activities against Candida species and Aspergillus niger. Most of 5,8-quinazolinediones 3-5 generally exhibited potent antifungal activity. 6-Arylamino-7-chloro-5,8-quinazolinediones (3) generally showed more potent antifungal activity than 7-arylthio-5,8-quinzolinediones (4) and 6,7-bis-(arylthio)-5,8-quinazolinediones (5).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Antifungal Agents / pharmacology*
Aspergillus niger / drug effects
Candida / drug effects
Chromatography, Thin Layer
Fungi / drug effects
Indicators and Reagents
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Quinazolines / chemical synthesis*
Quinazolines / pharmacology*
Spectrometry, Mass, Electrospray Ionization
Structure-Activity Relationship

Substances

5,8-quinazolinedione
Antifungal Agents
Indicators and Reagents
Quinazolines