Palladium-catalyzed N-vinylation of sulfoximines

J Org Chem. 2004 Nov 26;69(24):8518-20. doi: 10.1021/jo0485583.

Abstract

New previously unavailable N-vinyl sulfoximines have been synthesized by intermolecular palladium-catalyzed coupling between sulfoximines and vinyl bromides in excellent yield. Hydrogenation of the vinyl moiety opens a novel way to alpha-branched N-alkyl sulfoximines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bromides / chemistry
  • Catalysis
  • Molecular Structure
  • Palladium / chemistry*
  • Stereoisomerism
  • Sulfonamides / chemical synthesis*
  • Sulfonamides / chemistry
  • Vinyl Compounds / chemical synthesis*
  • Vinyl Compounds / chemistry

Substances

  • Bromides
  • Sulfonamides
  • Vinyl Compounds
  • Palladium