Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora

Planta Med. 2004 Nov;70(11):1085-7. doi: 10.1055/s-2004-832652.

Abstract

Two known spirodihydrobenzofuran terpenes (1 and 2) were isolated from a mycelium extract of the fungus Stachybotrys nephrospora BCC 3900. Compound 1 (Mer-NF5003F or stachybotrydial) exhibited potent antiviral activity (the IC50 value of 4.32 microg/mL) comparable to the standard drug, acyclovir, while compound 2 was inactive against the HSV-1 virus. Both 1 and 2 possessed antiplasmodial activity (IC50 values of 0.85 and 0.15 microg/mL for 1 and 2, respectively), and were not toxic towards the Vero cell line. A regiospecific conversion of the dialdehyde 1 to the lactone 2 proceeded simply under acidic conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / administration & dosage
  • Antimalarials / pharmacology*
  • Antimalarials / therapeutic use
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / therapeutic use
  • Chlorocebus aethiops
  • Herpes Simplex / drug therapy
  • Herpesvirus 1, Human / drug effects*
  • Humans
  • Malaria, Falciparum / drug therapy
  • Microbial Sensitivity Tests
  • Parasitic Sensitivity Tests
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plasmodium falciparum / drug effects*
  • Stachybotrys*
  • Vero Cells / drug effects

Substances

  • Antimalarials
  • Antiviral Agents
  • Plant Extracts