Abstract
Two known spirodihydrobenzofuran terpenes (1 and 2) were isolated from a mycelium extract of the fungus Stachybotrys nephrospora BCC 3900. Compound 1 (Mer-NF5003F or stachybotrydial) exhibited potent antiviral activity (the IC50 value of 4.32 microg/mL) comparable to the standard drug, acyclovir, while compound 2 was inactive against the HSV-1 virus. Both 1 and 2 possessed antiplasmodial activity (IC50 values of 0.85 and 0.15 microg/mL for 1 and 2, respectively), and were not toxic towards the Vero cell line. A regiospecific conversion of the dialdehyde 1 to the lactone 2 proceeded simply under acidic conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / administration & dosage
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Antimalarials / pharmacology*
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Antimalarials / therapeutic use
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Antiviral Agents / administration & dosage
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Antiviral Agents / pharmacology*
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Antiviral Agents / therapeutic use
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Chlorocebus aethiops
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Herpes Simplex / drug therapy
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Herpesvirus 1, Human / drug effects*
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Humans
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Malaria, Falciparum / drug therapy
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Microbial Sensitivity Tests
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Parasitic Sensitivity Tests
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plasmodium falciparum / drug effects*
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Stachybotrys*
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Vero Cells / drug effects
Substances
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Antimalarials
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Antiviral Agents
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Plant Extracts