Cellular and physiological effects of short-chain fatty acids

Mini Rev Med Chem. 2004 Oct;4(8):839-45. doi: 10.2174/1389557043403288.

Abstract

Short chain fatty acids (SCFA) have multiple in vivo and in vitro effects including cell cycle arrest and induction of protein synthesis, differentiation, and apoptosis. Butyrate or derivatives have promise for treating inflammatory bowel disease and colon cancer. Genomic and proteomic analysis have generated new knowledge on function and applications for SCFA.

Publication types

  • Review

MeSH terms

  • Animals
  • Butyrates / metabolism
  • Butyrates / pharmacology
  • Fatty Acids, Volatile* / metabolism
  • Fatty Acids, Volatile* / pharmacology
  • Fatty Acids, Volatile* / physiology
  • Humans
  • Inflammation / drug therapy
  • Inflammation / metabolism
  • Intestinal Mucosa / metabolism
  • Molecular Structure
  • Neoplasms / drug therapy
  • Thrombosis / etiology
  • Thrombosis / therapy

Substances

  • Butyrates
  • Fatty Acids, Volatile