Abstract
Starting from 2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethylamine and 6-methylpicolinic acid, 9-methoxy-5-methyl-1-(6-methylpyridin-2-yl)-6H-pyrido[4,3-b]carbazole 10 and its 6-alkylderivatives 12-17 were obtained. The newly obtained compounds showed significant cytostatic activity against cultured L1210 cells and high cytotoxicity towards various human tumor cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Line, Tumor
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Cells, Cultured
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Drug Screening Assays, Antitumor
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Ellipticines / chemistry
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Ellipticines / pharmacology*
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Humans
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Indicators and Reagents
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Leukemia L1210 / drug therapy
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Mice
Substances
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Antineoplastic Agents, Phytogenic
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Ellipticines
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Indicators and Reagents
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olivacine