Synthesis, structure, and cytostatic properties of new olivacine derivatives

Arch Pharm (Weinheim). 2004 Nov;337(11):599-604. doi: 10.1002/ardp.200400893.

Abstract

Starting from 2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethylamine and 6-methylpicolinic acid, 9-methoxy-5-methyl-1-(6-methylpyridin-2-yl)-6H-pyrido[4,3-b]carbazole 10 and its 6-alkylderivatives 12-17 were obtained. The newly obtained compounds showed significant cytostatic activity against cultured L1210 cells and high cytotoxicity towards various human tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Cells, Cultured
  • Drug Screening Assays, Antitumor
  • Ellipticines / chemistry
  • Ellipticines / pharmacology*
  • Humans
  • Indicators and Reagents
  • Leukemia L1210 / drug therapy
  • Mice

Substances

  • Antineoplastic Agents, Phytogenic
  • Ellipticines
  • Indicators and Reagents
  • olivacine