Ligand discovery using small molecule microarrays

J Pharmacol Exp Ther. 2005 Apr;313(1):1-7. doi: 10.1124/jpet.104.076943. Epub 2004 Nov 10.

Abstract

Small molecule microarrays have recently been used to identify ligands for several proteins, and several themes regarding screening strategies and limitations have emerged. In this review, some of the technical issues related to the manufacture and screening of small molecule microarrays, as well as prospects for small molecule microarrays in several areas of drug discovery and chemistry, are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Combinatorial Chemistry Techniques
  • Drug Evaluation, Preclinical
  • Humans
  • Ligands*
  • Oligonucleotide Array Sequence Analysis*
  • Receptors, Cell Surface / drug effects
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / physiology*

Substances

  • Ligands
  • Receptors, Cell Surface