Polymorphisms of the fimbria fim3 gene of Bordetella pertussis strains isolated in Canada

J Clin Microbiol. 2004 Nov;42(11):5364-7. doi: 10.1128/JCM.42.11.5364-5367.2004.

Abstract

The fim genes which code for the fimbria protective antigens present in both the inactivated whole-cell and acellular vaccines were analyzed in 86 Canadian Bordetella pertussis isolates. At least one of the novel mutations identified was found to involve a surface epitope that has been mapped by serum antibodies from infected or vaccinated subjects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antigens, Bacterial / chemistry
  • Antigens, Bacterial / genetics*
  • Antigens, Bacterial / immunology
  • Bordetella pertussis / classification
  • Bordetella pertussis / genetics
  • Bordetella pertussis / isolation & purification*
  • Bordetella pertussis / metabolism
  • Canada
  • Fimbriae Proteins / chemistry
  • Fimbriae Proteins / genetics*
  • Fimbriae Proteins / immunology
  • Humans
  • Molecular Sequence Data
  • Mutation
  • Pertussis Vaccine
  • Polymorphism, Genetic*
  • Sequence Analysis, DNA
  • Serotyping
  • Virulence Factors, Bordetella / chemistry
  • Virulence Factors, Bordetella / genetics*
  • Virulence Factors, Bordetella / immunology
  • Whooping Cough / microbiology
  • Whooping Cough / prevention & control

Substances

  • Antigens, Bacterial
  • Pertussis Vaccine
  • Virulence Factors, Bordetella
  • fim3 protein, Bordetella
  • Fimbriae Proteins

Associated data

  • GENBANK/AY464179
  • GENBANK/AY464180
  • GENBANK/AY464181