Assembling the mitochondrial outer membrane

Nat Struct Mol Biol. 2004 Nov;11(11):1044-8. doi: 10.1038/nsmb852.

Abstract

The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into functional complexes. A recently discovered sorting and assembly machinery (SAM complex) is essential for integration and assembly of outer-membrane proteins, revealing unexpected connections to mitochondrial evolution and morphology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Apoptosis
  • Cytosol / metabolism
  • Fungal Proteins / physiology
  • Humans
  • Intracellular Membranes / metabolism*
  • Mitochondria / metabolism
  • Mitochondria / pathology*
  • Mitochondrial Proteins / chemistry
  • Mitochondrial Proteins / metabolism
  • Models, Biological
  • Molecular Chaperones / metabolism
  • Plant Proteins / metabolism
  • Protein Transport

Substances

  • Fungal Proteins
  • Mitochondrial Proteins
  • Molecular Chaperones
  • Plant Proteins
  • Adenosine Triphosphate