Intoxications with amphetamine derivatives represent an important problem of clinical and forensic toxicology. Even if distribution of the drug group has been legally forbidden, they continue to pose serious threats, linked to their uncontrolled administration which frequently leads to lethal intoxications. We present a case of intoxication in a 17-year-old male with amphetamine derivate--MDMA, Ecstasy. Clinical analysis documented an acute multi-organ failure, in particular pronounced hepatic and renal insufficiency, disseminated intravascular clotting (DIC). The comprehensive diagnosis and resulting discharge abstract of the acute poisoning were confirmed by postmortem investigations.