Low vitamin D status in children with sickle cell disease

J Pediatr. 2004 Nov;145(5):622-7. doi: 10.1016/j.jpeds.2004.06.055.

Abstract

Objectives: To examine vitamin D status in children with sickle cell disease (SCD)-SS and its relation to season and dietary intake.

Study design: Growth, dietary intake, 25-hydroxyvitamin D (25-OHD), and parathyroid hormone levels were measured. Children with low and normal vitamin D status were compared. Low vitamin D status was defined as a serum concentration of 25-OHD <27.5 nmol/L. Serum 25-OHD and parathyroid hormone levels were compared among children with SCD-SS and healthy children.

Results: Children with SCD-SS (n=65), 5 to 18 years of age, were evaluated. Mean (+/-SD) serum 25-OHD concentration was 25.5 +/- 12.8 nmol/L; 65% of subjects had low vitamin D status. Low vitamin D prevalence was highest during spring (100%). Children with SCD-SS were at higher risk for low vitamin D status than healthy children. Vitamin D intake was lower in subjects with SCD-SS and low vitamin D than those with normal serum vitamin D status (P <.05).

Conclusions: Low serum vitamin D status was highly prevalent in black children with SCD-SS. Vitamin D status was associated with season and dietary intake.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Anemia, Sickle Cell / blood*
  • Black People
  • Body Weights and Measures
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Diet
  • Female
  • Humans
  • Male
  • Nutritional Status
  • Parathyroid Hormone / blood
  • Seasons
  • Sexual Maturation
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood*

Substances

  • Parathyroid Hormone
  • Vitamin D
  • 25-hydroxyvitamin D