BINOL catalyzed enantioselective addition of titanium phenylacetylide to aromatic ketones

Chem Commun (Camb). 2004 Nov 7:(21):2448-9. doi: 10.1039/b408654f. Epub 2004 Sep 21.

Abstract

An enantioselective addition of titanium phenylacetylide to ketones, promoted by BINOL, is described; this new enantioselective protocol gives high enantiomeric excess (up to 90% ee) with aromatic ketones using a simple procedure without pyrophoric or expensive reagents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Catalysis
  • Hydrocarbons, Aromatic / chemistry*
  • Ketones / chemistry*
  • Naphthols / chemistry*
  • Organometallic Compounds / chemical synthesis*
  • Stereoisomerism
  • Titanium / chemistry*

Substances

  • Alkynes
  • BINOL, naphthol
  • Hydrocarbons, Aromatic
  • Ketones
  • Naphthols
  • Organometallic Compounds
  • Titanium