Abstract
One-week cold exposure of mice led to a 2-fold increase in the density of alpha1-adrenoceptors in brown adipose tissue. The density of alpha1-adrenoceptors returned to normal after adaptation to cold for 2 weeks. The reduced Ca2+ signaling in stem cells of brown fat activated via beta-adrenoceptors and cAMP was transformed into the Ca2+-system induced by alpha1-adrenoceptors and similar to that in mature brown adipocytes.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acclimatization*
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Adipocytes / drug effects
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Adipocytes / metabolism*
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Adipose Tissue, Brown / cytology*
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Adrenergic alpha-Agonists / pharmacology
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Adrenergic beta-Agonists / pharmacology
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Animals
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Calcium Signaling* / drug effects
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Cells, Cultured
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Cold Temperature*
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Cyclic AMP / metabolism
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Imidazoles / pharmacology
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Isoproterenol / pharmacology
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Male
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Mice
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Mice, Inbred Strains
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Norepinephrine / pharmacology
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Receptors, Adrenergic, alpha / metabolism
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Time Factors
Substances
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Adrenergic alpha-Agonists
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Adrenergic beta-Agonists
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Imidazoles
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Receptors, Adrenergic, alpha
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Cyclic AMP
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Isoproterenol
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cirazoline
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Norepinephrine