Abstract
Six coumarin derivatives [three 4-phenylcoumarins (Mammea A/AA, Mammea A/BA and MAB 3), two 4-n-propylcoumarins (Mammea B/BB and Mammea B/BA) and one 4-n-pentylcoumarin (Mammea C/OB)], 1,5-dihydroxyxanthone and 1-methoxy-5-hydroxyxanthone have been isolated from the stem bark of Mammea africana Sabine collected in Cameroon. Although known, the structures of the coumarin derivatives were confirmed by spectral analysis, including two-dimensional nuclear magnetic resonance. All the coumarin compounds showed noteworthy cytotoxicity against the human 9-KB cell line. Both of the 4-n-propylcoumarins were also found to exhibit significant activity against Staphylococcus aureus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Division / drug effects
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Chemistry, Pharmaceutical
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Chromatography, Gel / methods
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Coumarins / chemistry
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Coumarins / isolation & purification
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Coumarins / pharmacology*
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Humans
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Mammea / chemistry*
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Plant Bark / chemistry
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Staphylococcus aureus / drug effects
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Tumor Cells, Cultured
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Xanthones / chemistry
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Xanthones / isolation & purification
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Xanthones / pharmacology
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents, Phytogenic
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Coumarins
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Plant Extracts
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Xanthones
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coumarin