Ophthalmic therapeutic systems, which rank among the drugs of the second and third generation, make possible prolonged and controlled drug release, or the introduction of the drug direct into the site of action (a specific eye tissue) with minimal distribution into the adjacent tissues. The group mainly consists of solid ophthalmic preparations, in a lesser extent there are systems developed from hydrogels, colloidal carriers, etc. The present review lists both insoluble ophthalmic therapeutic systems and those soluble in water (degradable, erodible). Insoluble systems include membrane-controlled ophthalmic therapeutic systems (e.g. Ocusert), therapeutic eye lenses, eye implants, and other insoluble preparations. In the group of soluble preparations, topical inserts and systems are described, which are introduced into eye tissues as implants or injections.