Abstract
Sixty-three stool samples and five bile samples were prospectively collected from 33 patients receiving intravenous vancomycin therapy and were quantitatively analyzed for vancomycin by a competitive immunoassay. Vancomycin was excreted via bile into the stools of almost all patients at concentrations of 3.3 to 94.8 microg/ml after >/=5 days of a therapy of 1 g every 12 h.
MeSH terms
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / metabolism*
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Bacterial Proteins / chemistry
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Bile / metabolism*
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Carbon-Oxygen Ligases / chemistry
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Cross-Sectional Studies
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Drug Therapy, Combination / metabolism
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Enterococcus / drug effects*
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Feces / chemistry*
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Feces / microbiology
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Fluorescence Polarization Immunoassay
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Gentamicins / metabolism
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Gram-Positive Bacterial Infections / microbiology*
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Humans
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Injections, Intravenous
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Rectum / microbiology*
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Vancomycin / administration & dosage
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Vancomycin / metabolism*
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Vancomycin Resistance
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Gentamicins
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VanA ligase, Bacteria
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Vancomycin
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Carbon-Oxygen Ligases