2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels

Bioorg Med Chem Lett. 2004 Dec 6;14(23):5727-30. doi: 10.1016/j.bmcl.2004.09.057.

Abstract

2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide and close analogues inhibit glucose stimulated insulin release through activation of Kir6.2/SUR1 K(ATP) channels of beta cells.

MeSH terms

  • ATP-Binding Cassette Transporters / agonists
  • ATP-Binding Cassette Transporters / metabolism*
  • Adenosine Triphosphate / metabolism
  • Animals
  • Benzamides / chemistry*
  • Benzamides / pharmacology*
  • Benzothiadiazines / chemistry
  • Benzothiadiazines / pharmacology
  • Diazoxide / analogs & derivatives*
  • Diazoxide / chemistry
  • Diazoxide / pharmacology
  • Islets of Langerhans / drug effects
  • Islets of Langerhans / metabolism
  • Potassium Channels / agonists
  • Potassium Channels / metabolism*
  • Potassium Channels, Inwardly Rectifying / agonists
  • Potassium Channels, Inwardly Rectifying / metabolism*
  • Pyridines / chemistry
  • Pyridines / pharmacology
  • Rats
  • Receptors, Drug / agonists
  • Receptors, Drug / metabolism*
  • Sulfonylurea Receptors
  • Thiadiazines / chemistry
  • Thiadiazines / pharmacology

Substances

  • 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide
  • ATP-Binding Cassette Transporters
  • Abcc8 protein, rat
  • BPDZ 62
  • Benzamides
  • Benzothiadiazines
  • Kir6.2 channel
  • Potassium Channels
  • Potassium Channels, Inwardly Rectifying
  • Pyridines
  • Receptors, Drug
  • Sulfonylurea Receptors
  • Thiadiazines
  • Adenosine Triphosphate
  • Diazoxide