Three novel single nucleotide polymorphisms (SNPs) of the CYP2B6 gene in Japanese individuals

Drug Metab Pharmacokinet. 2004 Apr;19(2):155-8. doi: 10.2133/dmpk.19.155.

Abstract

We sequenced all exons and exon-intron junctions of the CYP2B6 gene from 200 Japanese individuals. We found three novel single nucleotide polymorphisms (SNPs) (1375A>G, 1427G>A and 1454A>T) causing amino acid substitutions (Met(459)Val, Gly(476)Asp and Gln(485)Leu in exon 9), respectively. The detected SNP was as follows: 1) SNP, 031226Hiratsuka01; GENE NAME, CYP2B6; ACCESSION NUMBER, AC023172; LENGTH, 25 base; 5'-CAGAACTTCTCCA/GTGGCCAGCCCCG-3'. 2) SNP, 031226Hiratsuka02; GENE NAME, CYP2B6; ACCESSION NUMBER, AC023172; LENGTH, 25 base; 5'-CCCAGGAGTGTGG/ATGTGGGCAAAAT-3'. 3) SNP, 031226Hiratsuka03; GENE NAME, CYP2B6; ACCESSION NUMBER, AC023172; LENGTH, 25 base; 5'-CCCCAACATACCA/TGATCCGCTTCCT-3'.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Aryl Hydrocarbon Hydroxylases / genetics*
  • Cytochrome P-450 CYP2B6
  • DNA Primers
  • Exons / genetics
  • Gene Frequency
  • Humans
  • Introns / genetics
  • Japan / epidemiology
  • Molecular Sequence Data
  • Oxidoreductases, N-Demethylating / genetics*
  • Polymorphism, Single Nucleotide
  • Reverse Transcriptase Polymerase Chain Reaction

Substances

  • DNA Primers
  • Aryl Hydrocarbon Hydroxylases
  • CYP2B6 protein, human
  • Cytochrome P-450 CYP2B6
  • Oxidoreductases, N-Demethylating

Associated data

  • GENBANK/AC023172