Neuropathology: many paths lead to hereditary spastic paraplegia

Curr Biol. 2004 Oct 26;14(20):R903-4. doi: 10.1016/j.cub.2004.09.076.

Abstract

Studies with animal models are providing new insights into the pathology of hereditary spastic paraplegia, particularly how mutations in multiple, converging pathways can lead to this family of neuropathies.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / metabolism
  • Axons / metabolism*
  • Humans
  • Microtubules / metabolism
  • Mutation / genetics
  • Myelin Proteins / genetics
  • Myelin Proteins / metabolism*
  • Neuroglia / metabolism*
  • Spastic Paraplegia, Hereditary / genetics*
  • Spastic Paraplegia, Hereditary / metabolism
  • Spastic Paraplegia, Hereditary / pathology*
  • Spastin
  • Synaptic Vesicles / metabolism

Substances

  • Myelin Proteins
  • Adenosine Triphosphatases
  • Spastin
  • SPAST protein, human