Abstract
Studies with animal models are providing new insights into the pathology of hereditary spastic paraplegia, particularly how mutations in multiple, converging pathways can lead to this family of neuropathies.
MeSH terms
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Adenosine Triphosphatases / metabolism
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Axons / metabolism*
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Humans
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Microtubules / metabolism
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Mutation / genetics
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Myelin Proteins / genetics
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Myelin Proteins / metabolism*
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Neuroglia / metabolism*
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Spastic Paraplegia, Hereditary / genetics*
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Spastic Paraplegia, Hereditary / metabolism
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Spastic Paraplegia, Hereditary / pathology*
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Spastin
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Synaptic Vesicles / metabolism
Substances
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Myelin Proteins
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Adenosine Triphosphatases
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Spastin
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SPAST protein, human