Tichocarpols A and B, two novel phenylpropanoids with feeding-deterrent activity from the red alga Tichocarpus crinitus

Takahiro Ishii; Tatsufumi Okino; Minoru Suzuki; Yuji Machiguchi

doi:10.1021/np0498509

Tichocarpols A and B, two novel phenylpropanoids with feeding-deterrent activity from the red alga Tichocarpus crinitus

J Nat Prod. 2004 Oct;67(10):1764-6. doi: 10.1021/np0498509.

Authors

Takahiro Ishii¹, Tatsufumi Okino, Minoru Suzuki, Yuji Machiguchi

Affiliation

¹ Division of Material Science, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060-0810, Japan.

PMID: 15497960
DOI: 10.1021/np0498509

Abstract

Two novel phenylpropanoic acid derivatives, tichocarpol A (1) and tichocarpol B (2), were isolated along with floridoside and isethionic acid from the red alga Tichocarpus crinitus. The structures of these novel metabolites were elucidated using a combination of spectral (1D and 2D NMR techniques and ESIMS) and chemical methods. Compounds 1, 2, and floridoside exhibited feeding-deterrent activity against the sea urchin Strongylocentrotus intermedius.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Feeding Behavior / drug effects*
Japan
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Phenylpropionates / chemistry
Phenylpropionates / isolation & purification*
Phenylpropionates / pharmacology
Rhodophyta / chemistry*
Sea Urchins / drug effects*

Substances

Phenylpropionates
tichocarpol A
tichocarpol B