Abstract
The interaction of cytotoxic T lymphocytes with major histocompatibility complex (MHC)-peptide complexes is a critical step toward the initiation and propagation of specific immune responses against viral infection. Here we review new evidence, taking Epstein-Barr virus as an example, showing that defective ribosomal products provide an important supply of endogenous peptides for entry into the MHC class I antigen-presentation pathway.
MeSH terms
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Animals
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Antigen Presentation*
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Epstein-Barr Virus Nuclear Antigens / metabolism*
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Herpesvirus 4, Human / immunology*
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Herpesvirus 4, Human / pathogenicity*
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Histocompatibility Antigens Class I / immunology
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Humans
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Peptides / immunology
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Peptides / metabolism*
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Proteasome Endopeptidase Complex / metabolism
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T-Lymphocytes, Cytotoxic / immunology
Substances
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Epstein-Barr Virus Nuclear Antigens
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Histocompatibility Antigens Class I
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Peptides
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Proteasome Endopeptidase Complex
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EBV-encoded nuclear antigen 1