Retinoic acid: an educational "vitamin elixir" for gut-seeking T cells

J Rodrigo Mora; Ulrich H von Andrian

doi:10.1016/j.immuni.2004.10.002

Retinoic acid: an educational "vitamin elixir" for gut-seeking T cells

Immunity. 2004 Oct;21(4):458-60. doi: 10.1016/j.immuni.2004.10.002.

Authors

J Rodrigo Mora¹, Ulrich H von Andrian

Affiliation

¹ The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

PMID: 15485623
DOI: 10.1016/j.immuni.2004.10.002

Abstract

T cell priming by dendritic cells (DC) from gut-associated lymphoid tissues gives rise to effector cells with pronounced gut tropism. The mechanism for DC-dependent imprinting of gut specificity has remained unknown. New findings point to retinoic acid, which is uniquely produced by intestinal DC, but not by DC from other lymphoid organs.

Publication types

Comment

MeSH terms

Animals
Antineoplastic Agents / pharmacology*
Dendritic Cells / immunology
Digestive System / immunology*
Humans
Lymphocyte Activation / drug effects*
Lymphocyte Activation / immunology
Lymphoid Tissue / immunology
Receptors, Lymphocyte Homing / immunology
Signal Transduction / immunology*
T-Lymphocytes / drug effects*
T-Lymphocytes / immunology
Tretinoin / pharmacology*

Substances

Antineoplastic Agents
Receptors, Lymphocyte Homing
Tretinoin