Abstract
The responses of plasma cortisol and adrenocorticotropic hormone (ACTH) were examined to intravenous injection of recombinant bovine tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (INF-gamma) in Holstein cows. INF-gamma induced dose-dependent rises in the plasma levels of both cortisol and ACTH, while TNF-alpha induced comparable plasma cortisol responses with much smaller rises in plasma ACTH. The results suggest a direct stimulatory action of TNF-alpha on cortisol secretion from the adrenal gland in cattle.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenal Cortex / drug effects*
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Adrenal Cortex / physiology
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Adrenocorticotropic Hormone / blood*
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Adrenocorticotropic Hormone / pharmacokinetics
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Animals
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Cattle / blood
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Cattle / physiology*
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Dose-Response Relationship, Drug
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Female
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Hydrocortisone / blood*
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Hydrocortisone / pharmacokinetics
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Injections, Intravenous / veterinary
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Interferon-gamma / administration & dosage
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Interferon-gamma / pharmacology*
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Random Allocation
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Recombinant Proteins / administration & dosage
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Recombinant Proteins / pharmacology
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Tumor Necrosis Factor-alpha / administration & dosage
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Tumor Necrosis Factor-alpha / pharmacology*
Substances
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Recombinant Proteins
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Tumor Necrosis Factor-alpha
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Interferon-gamma
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Adrenocorticotropic Hormone
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Hydrocortisone